Journal
PROTEOMICS
Volume 8, Issue 1, Pages 21-27Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pmic.200700598
Keywords
MALDI; normalisation; SELDI; total ion current
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Normalisation of data to minimise the impact of technical variation on comparative sample analysis is often carried out. Using SELDI data as a model, we have examined the effects of normalisation by TIC which is commonly used for MS data. Significant intergroup differences in normalisation factor were found for serum profiles which could not be explained by experimental factors, implying that normalisation by TIC may in some situations also normalise biological differences and should be systematically evaluated.
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