Journal
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Volume 82, Issue 11, Pages 2915-2924Publisher
WILEY
DOI: 10.1002/prot.24562
Keywords
EF-hand; EF-lobe; symmetry; calcium; structural comparison; evolution; function
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We have analyzed the conformations of EF-lobes, adjacent pairs of EF-hand domains, in a coordinate system based on the approximate two-fold (z) axis that relates the two EF-hands. Two parameters - dE(O), the azimuthal angle between the y-axis and the projection of the offset vector to helix E onto the yz-plane, and dF(O), the difference angle between the two helices (F1 and F2) of odd and even domainscharacterize the openness of a single EF-hand domain and of an EF-lobe, respectively. We describe and compare values of dE(O) and of dF(O) for EF-hand proteins of five subfamiliesCTER, CPV, S100, PARV, CALPin calci- and apo- forms, with and without bound target proteins. Each subfamily has characteristic changes associated with binding calcium and/or target proteins. Proteins 2014; 82:2915-2924. (c) 2014 Wiley Periodicals, Inc.
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