Journal
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Volume 79, Issue 7, Pages 2109-2121Publisher
WILEY
DOI: 10.1002/prot.23032
Keywords
water molecules; kinase; selectivity; binding site similarity; drug design
Categories
Funding
- The Institute of Cancer Research
- Cancer Research UK [CRUK] [C309/A8274]
- EPSRC
- NHS
- Cancer Research UK [11566] Funding Source: researchfish
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Deregulation of protein kinases is associated with numerous diseases, making them important targets for drug discovery. The majority of drugs target the catalytic site of these proteins, but due to the high level of similarity within the ATP binding sites of protein kinases, it is often difficult to achieve the required pharmacological selectivity. In this study, we describe the identification and subsequent analysis of water patterns in the ATP binding sites of 171 protein kinase structures, comprising 19 different kinases from various branches of the kinome, and demonstrate that structurally similar binding sites often have significantly different water patterns. We show that the observed variations in water patterns of different, but structurally similar kinases can be exploited in the structure-based design of potent and selective kinase inhibitors.
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