Journal
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Volume 76, Issue 3, Pages 598-607Publisher
WILEY
DOI: 10.1002/prot.22373
Keywords
SCOP; gene ontology; functional annotation; protein domain; protein function
Categories
Funding
- Spanish Ministry for Education and Science [B102006-15318, PIE 2006201240]
Ask authors/readers for more resources
Most proteins are organized in domains which can be seen as independent modular units in terms of molecular function (MF). Nevertheless, current functional annotations are done on a whole-chain basis without associating specific functions to the individual domains. We present here an automatic method for discerning which particular structural domain within a protein is responsible for a given MF originally attributed to the whole protein. By annotating the SCOP structural domains with gene ontology terms using this method, we obtained the first large-scale functional annotation at the domain level. We performed a large-scale comparison of these annotations with the ones implicit in the functional annotations of Inter-pro signatures, showing that the performance of this method is globally better. We also discuss in detail some particular examples. Generated automatically and available online, this resource could be the basis for future manually curated annotations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available