4.6 Article

CDtoolX, a downloadable software package for processing and analyses of circular dichroism spectroscopic data

Journal

PROTEIN SCIENCE
Volume 27, Issue 9, Pages 1717-1722

Publisher

WILEY
DOI: 10.1002/pro.3474

Keywords

circular dichroism spectroscopy; data analyses; data processing; synchrotron radiation circular dichroism; data archiving; calibration

Funding

  1. Bioinformatics and Biological Resources (BBR) Grant from the U.K. Biotechnology and Biological Sciences Research Council (BBSRC) [P024092, J019135]
  2. BBSRC [BB/P024092/1] Funding Source: UKRI

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Circular dichroism (CD) spectroscopy is a highly used method for the examination and characterization of proteins, including, amongst other features, their secondary and tertiary structures, thermal stability, comparisons of wildtype and mutant proteins, and monitoring the binding of small molecules, folding/unfolding pathways, and formation of macromolecular complexes. This article describes CDtoolX, a new, user-friendly, free-to-download-and-use software program that enables processing, displaying, archiving, calibrating, comparisons, and analyses of CD and synchrotron radiation circular dichroism spectroscopic data.

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