Journal
PROTEIN SCIENCE
Volume 23, Issue 5, Pages 526-538Publisher
WILEY-BLACKWELL
DOI: 10.1002/pro.2441
Keywords
cytokine; receptors; antagonist; agonist; interleukin; inflammation
Categories
Funding
- NIH [AI081928, AI079217]
- Oklahoma Agricultural Experiment Station at Oklahoma State University [OKL02848]
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Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1 and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.
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