Journal
PROTEIN SCIENCE
Volume 19, Issue 11, Pages 2186-2195Publisher
WILEY
DOI: 10.1002/pro.504
Keywords
alpha-peptide; beta-peptide; helix; peptide stability; molecular dynamics
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Funding
- National Center of Competence in Research (NCCR) in Structural Biology
- Swiss National Science Foundation [200020-121913]
- European Research Council [228076]
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The right-handed alpha-helix is the dominant helical fold of alpha-peptides, whereas the left-handed 3(14)-helix is the dominant helical fold of beta-peptides. Using molecular dynamics simulations, the properties of alpha-helical alpha-peptides and 3(14)-helical beta-peptides with different C-terminal protonation states and in the solvents water and methanol are compared. The observed energetic and entropic differences can be traced to differences in the polarity of the solvent-accessible surface area and, in particular, the solute dipole moments, suggesting different reasons for their stability.
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