Journal
PROTEIN SCIENCE
Volume 13, Issue 10, Pages 2825-2828Publisher
WILEY
DOI: 10.1110/ps.04688204
Keywords
proteins; protein density; average density; molecular weight dependence; protein crystallography; analytical ultracentrifugation
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The mass density of proteins is a relevant basic biophysical quantity. It is also a useful input parameter, for example, for three-dimensional structure determination by protein crystallography and studies of protein oligomers in solution by analytic ultracentrifugation. We have performed a critical analysis of published, theoretical, and experimental investigations about this issue and concluded that the average density of proteins is not a constant as often assumed. For proteins with a molecular weight below 20 kDa, the average density exhibits a positive deviation that increases for decreasing molecular weight. A simple molecular-weight-depending function is proposed that provides a more accurate estimate of the average protein density.
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