Journal
PROTEIN SCIENCE
Volume 13, Issue 11, Pages 2852-2856Publisher
WILEY
DOI: 10.1110/ps.04947204
Keywords
aggregation; Lewy bodies; oxidative stress; Parkinson's disease; alpha-synuclein; tyrosine
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Funding
- NIEHS NIH HHS [R21 ES 10774] Funding Source: Medline
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alpha-Synuclein is the main component of the intracellular protein aggregates in neurons of patients with Parkinson's disease. The occurrence of the disease is associated with oxidative damage. Although it is known that peroxidative chemistry leads to the aggregation of alpha-synuclein in vitro, the specific amino acid types of alpha-synuclein involved in this type of aggregation have not been identified. We show, using human cytochrome c plus H2O2 as the source oxidative stress, that the tyrosines of alpha-synuclein are required for aggregation. The studies reveal the chemical basis for a crucial step in the aggregation process.
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