Journal
PROTEIN AND PEPTIDE LETTERS
Volume 25, Issue 9, Pages 815-821Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866525666180905110619
Keywords
S-sulfenylation site; statistical learning; feature representation; tool development; computational prediction tools; regulatory networks
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Funding
- JSPS KAKENHI [17K20009]
- Grants-in-Aid for Scientific Research [17K20009] Funding Source: KAKEN
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Background: Cysteine S-sulfenylation is a major type of dynamic post-translational modification of the protein that plays an important role in regulating many biological processes in both of prokaryotic and eukaryotic species. To understand the function of S-sulfenylated proteins, identification of S-sulfenylation sites is an essential step. Due to numerous restrictions of experimental methods, computational prediction of the potential S-sulfenylation sites becomes popular. In this review, we discuss the recent development and challenges in protein S-sulfenylation site prediction from the available datasets, algorithms and accessible services. We also demonstrate the encountered limitation and future perspective of the computational prediction tools. Conclusion: The development of S-sulfenylation site prediction and their application is an emerging field of protein bioinformatics research. Accurate predictors are expected to identify general and species-specific S-sulfenylation sites when more experimental annotation data are available. Combining experimental and computational technologies will definitely accelerate an understanding of protein S-sulfenylation, discovering regulatory networks in living organisms.
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