Journal
PROTEIN AND PEPTIDE LETTERS
Volume 21, Issue 11, Pages 1102-1120Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866521666140807114240
Keywords
Brain; hydrophobic ion-pairing (HIP) complex; nasal; ocular; parenteral; polymeric nanoparticles; protein and peptide drug delivery; pulmonary; transdermal
Categories
Funding
- NIH [R01EY09171, RO1EY10659]
- NATIONAL EYE INSTITUTE [R01EY010659, R01EY009171] Funding Source: NIH RePORTER
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Proteins and peptides are widely indicated in many diseased states. Parenteral route is the most commonly employed method of administration for therapeutic proteins and peptides. However, requirement of frequent injections due to short in vivo half-life results in poor patient compliance. Non-invasive drug delivery routes such as nasal, transdermal, pulmonary, and oral offer several advantages over parenteral administration. Intrinsic physicochemical properties and low permeability across biological membrane limit protein delivery via non-invasive routes. One of the strategies to improve protein and peptide absorption is by delivering through nanostructured delivery carriers. Among nanocarriers, polymeric nanoparticles (NPs) have demonstrated significant advantages over other delivery systems. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following oral, nasal, pulmonary, parenteral, transdermal, and ocular administrations.
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