Journal
PROTEIN AND PEPTIDE LETTERS
Volume 19, Issue 1, Pages 29-39Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986612798472794
Keywords
Cellulase; enzyme; optimal pH; optimal temperature; prediction
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Funding
- Guangxi Science Foundation [07-109-001A, 08-115-011, 09322001, 10-046-06, 11-031-11, 2010GXNSFF013003, 2010GXNSFA013046]
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Cellulase is an important enzyme widely used in various industries, and now in fermentation of biomass into biofuels. Enzymatic function of cellulase is closely related to pH, temperature, substrate concentration, etc. For newly found cellulase, it would be more cost-effective to predict its optimal pH and temperature before conducting the costly experiments. In this study, we used a 20-2 feedforward backpropagation neural network to build the relationship between information obtained from primary structure of cellulase with optimal pH and temperature to predict the optimal pH and temperature in cellulases. The results show that the amino-acid distribution probability representing the primary structure of cellulase can predict both optimal pH and temperature, whereas various properties of amino acids related to the primary structure cannot do so.
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