Journal
PROTEIN AND PEPTIDE LETTERS
Volume 17, Issue 10, Pages 1296-1299Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986610792231401
Keywords
Crystal; cell wall; X-ray; latency
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Funding
- MIUR [RBRN07BMCT]
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PrkC is an important Ser/Thr membrane kinase of Staphylococcus aureus able to bind peptidoglycans through extra-cellular domains, denominated as PASTA. Upon peptidoglycan binding, PrkC is activated and stimulates bacterial growth and revival from latency. The entire extra-cellular region of PrkC (residues 378-664), containing three predicted PASTA domains and an extra-domain of unknown function, has been successfully crystallized using vapor-diffusion methods. The structure has been solved by Multiwavelength Anomalous Dispersion and refinement is in progress.
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