Journal
PROTEIN AND PEPTIDE LETTERS
Volume 15, Issue 5, Pages 536-540Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986608784567618
Keywords
antimicrobial peptide; innate immunity; host defense; signal sequence
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Funding
- US Public Health Service [R01 DE14897, R01 HL67871]
- Cystic Fibrosis Foundation
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Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.
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