Journal
PROTEIN AND PEPTIDE LETTERS
Volume 15, Issue 3, Pages 300-308Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986608783744207
Keywords
GPCR; heterodimerization; signaling; conformation
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G pretein coupled-receptors (GPCR) have been shown to form heterodimers or heterooligomers with various biochemical and/or pharmacological activity that are distinct from those of the corresponding monomers or homomers. Recent in vitro and in vivo experimental data have also shown novel functional roles of several orphan GPCRs as modulatory units of heterodimers and potentials for development of heterodimer-selective clinical agents. In this review, we summarize essential and latest knowledge as to GPCR heterodimerizations and the current issues to be solved in the near future.
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