4.0 Article

An Efficient and Facile Method for the Synthesis of Benzimidazoisoquinoline Derivatives via a Multicomponent Reaction

Journal

ACS COMBINATORIAL SCIENCE
Volume 18, Issue 1, Pages 65-69

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.5b00145

Keywords

benzimidazoisoquinoline; multicomponent reactions (MCRs); benzimidazole; nucleophilic substitution reaction; one-pot

Funding

  1. Scientific Research Foundation of Chongqing University of Arts and Sciences [R2013XY01, R2013XY02]
  2. Chongqing Science and Technology Commission [CSTC2013JCYJA50028]
  3. National Natural Science Foundations of China [81272598]
  4. SRF for ROCS, SEM
  5. Key Laboratory of Tumor Immunopathology, Ministry of Education of China [2013jsz102, 2015SZ0187]

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Two series of benzimidazoisoquinoline and fused benzimidazoisoquinoline-benzimidazole derivatives have been synthesized using an efficient one-pot procedure. This process involves an intramolecular nucleophilic substitution reaction and provides facile access to two series of complexes and potentially interesting biologically active scaffolds.

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