Palladium-Catalyzed Acylation/Alkenylation of Aryl Iodide: A Domino Approach Based on the Catellani-Lautens Reaction

A new palladium-catalyzed three-component coupling involving acylation/alkenylation of aryl iodide is reported. The reaction was carried out with readily available starting materials and gave the ortho-acylated styrene in moderate to good yields. Compared with previous Catellani-Lautens reactions, this reaction is the first example of introducing an acyl group at the ortho position of aryl iodides. The proposed Pd-IV complex, generated via oxidative addition of the carboxylic anhydrides, is a key intermediate for this transformation.