Androgen deprivation therapy and estrogen deficiency induced adverse effects in the treatment of prostate cancer

Androgen deprivation therapy (ADT) is the standard of care for metastatic prostate cancer and is increasingly used to treat asymptomatic patients with prostate-specific antigen recurrence after failed primary therapy. Although effective, ADT is associated with multiple adverse effects, many of which are related to the estrogen deficiency that occurs as a result of treatment. These include increased fracture risk, hot flashes, gynecomastia, serum lipid changes and memory loss. By providing clinicians with a greater awareness of the estrogen deficiency induced adverse effects from ADT, they can proactively intervene on the physical and psychological impact these effects have on patients. Prostate Cancer and Prostatic Diseases (2009) 12, 333-338; doi: 10.1038/pcan.2009.35; published online 1 September 2009