Journal
PROSTATE CANCER AND PROSTATIC DISEASES
Volume 13, Issue 1, Pages 6-11Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/pcan.2009.29
Keywords
caveolin-1; progression; angiogenesis; biomarkers
Categories
Funding
- NIH [R01 CA68814]
- Department of Defense [DAMD PC051247]
- NATIONAL CANCER INSTITUTE [R01CA068814] Funding Source: NIH RePORTER
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Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer. Prostate Cancer and Prostatic Diseases (2010) 13, 6-11; doi:10.1038/pcan.2009.29; published online 7 July 2009
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