Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 91, Issue 1-2, Pages 39-47Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2014.05.002
Keywords
n-3 PUFA; Age; Sex; Cholesterol efflux; Lipids and lipoproteins
Funding
- Natural Sciences and Engineering Research Council of Canada [217451]
- Canada Foundation for Innovation [3886]
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There is clear evidence of the effects of sex and age on the prevalence of cardiovascular disease. We investigated the interactions of dietary omega (n)-3 polyunsaturated fatty acids (PUFA), sex, and age on plasma lipids and lipoproteins in the offspring of C57BL/6 mice exposed to high, medium, or low n-3 PUFA at weaning and 16 weeks postweaning. There was an increase in plasma triglycerides from weaning to 16 weeks in male and female offspring; however, the high n-3 PUFA group showed a reduction in triglycerides in both sexes at 16 weeks. High n-3 PUFA caused an increase in plasma LDL-cholesterol from weaning to 16 weeks in male offspring; however, the LDL particle size was significantly larger in the high n-3 PUFA group. Plasma from male mice showed higher cholesterol efflux compared to females; high n-3 PUFA increased cholesterol efflux. Thus the effects of n-3 PUFA are age and sex dependent. (C) 2014 Elsevier Ltd. All rights reserved.
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