Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 88, Issue 1, Pages 43-47Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2012.03.008
Keywords
n-3 polyunsaturated fatty acids; DHA; EPA; Lipid rafts; Colon cancer; Chemoprevention; T-lymphocytes
Funding
- National Institute of Health [CA59034, CA129444]
- USDA [2010-34402-20875]
- NATIONAL CANCER INSTITUTE [R01CA129444, R01CA059034] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK071707] Funding Source: NIH RePORTER
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Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and multifaceted, resulting in an incomplete understanding of their molecular mechanisms of action. Here, we focus on a highly conserved mechanism of n-3 PUFA, which is the alteration of the organization of the plasma membrane. We highlight recent work demonstrating that enrichment of n-3 PUFA in the plasma membrane alters the lateral organization of membrane signaling assemblies (i.e. lipid rafts). This mechanism is central for n-3 PUFA regulation of downstream signaling, T-cell activation, transcriptional activation, and cytokine secretion. We conclude that these studies provide strong evidence for a predominant mechanism by which n-3 PUFA function in colon cancer prevention. (c) 2012 Elsevier Ltd. All rights reserved.
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