Journal
ACS CATALYSIS
Volume 5, Issue 10, Pages 6148-6152Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b01700
Keywords
hydroxylation; C-H functionalization; palladium; oxygenation; chemoselectivity
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Funding
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Natural Science Foundation of China [21325206, 21172006]
- National Young Top-notch Talent Support Program
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An efficient Pd-catalyzed oxime ether directed ortho C-H hydroxylation of arenes under neutral conditions has been developed. The efficiency of this hydroxylation is significantly improved by a ligand. Oxone, an inexpensive, readily available, and safe reagent, was employed as terminal oxidant and oxygen source. The challenging electron-deficient substrates could also be monohydroxylated in high efficiency. Drug modification with this protocol was also successfully demonstrated.
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