Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 85, Issue 1, Pages 9-28Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2011.02.001
Keywords
Plant stanols; Plant sterols; Phytostanols; Phytosterols; Plant stanol ester; Plant sterol ester; LDL-cholesterol; Dose-response; Meta-analysis
Funding
- Raisio Nutrition Ltd., Finland
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Purpose: To determine if plant stanols and plant sterols differ with respect to their low-density lipoprotein cholesterol (LDL-CH) lowering efficacies across a continuous dose range. Methods: Dose-response relationships were evaluated separately for plant stanols and plant sterols and reductions in LDL-CH, using a first-order elimination function. Results: Altogether, 113 publications and 1 unpublished study report (representing 182 strata) complied with the pre-defined inclusion and exclusion criteria and were included in the assessment. The maximal LDL-CH reductions for plant stanols (16.4%) and plant stanol ester (17.1%) were significantly greater than the maximal LDL-CH reductions for plant sterols (8.3%) and plant sterol ester (8.4%). These findings persisted in several additional analyses. Discussion and conclusions: Intakes of plant stanols in excess of the recommended 2 g/day dose are associated with additional and dose-dependent reductions in LDL-CH, possibly resulting in further reductions in the risk of coronary heart disease (CHD). (C) 2011 Elsevier Ltd. All rights reserved.
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