Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 85, Issue 3-4, Pages 137-141Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2011.06.006
Keywords
Desaturase; Fatty acids; Insulin resistance; Metabolic syndrome
Funding
- Ministry of High Education and Scientific Research of Tunisia
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This study aimed to determine plasma fatty acids pattern and to estimate desaturases activities in Tunisian subjects with metabolic syndrome (MetS). A total of 1975 adults were randomly selected from the Great Tunis region (Tunisia). MetS was defined according to the International Diabetes Federation criteria. Saturated and monounsaturated fatty acids levels and delta 9 desaturase activity were increased, but polyunsaturated fatty acids (PUFA) levels and delta 5 desaturase activity were decreased in patients with MetS. Using multivariate analysis, MetS was found inversely associated with PUFA; compared to first quartile, multi-adjusted odd ratios (95% confidence interval) of MetS were 0.80 (0.54-1.17), 0.47 (0.27-0.81) and 032 (0.15-0.68) for second, third and fourth quartiles of PUFA, respectively. Altered fatty acids; pattern in MetS is likely related to both dietary and metabolic changes. (C) 2011 Elsevier Ltd. All rights reserved.
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