Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 82, Issue 4-6, Pages 327-332Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2010.02.003
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Funding
- NHLBI NIH HHS [R01 HL068669] Funding Source: Medline
- NIAID NIH HHS [R56 AI068084, R01 AI068084-04, R01 AI068084, AI068084] Funding Source: Medline
- NIDCR NIH HHS [P50 DE016191-050004, P50-DE016191, P50 DE016191] Funding Source: Medline
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Dietary ingestion of fish is associated with a reduced risk for many common human illnesses. Fish oils are enriched with n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. Resolvins and protectins are newly discovered mediators that are enzymatically generated from these n-3 fatty acid precursors to orchestrate inflammation resolution. These natural compounds and their mimetics are providing intriguing evidence in model systems and translational research for cellular and molecular mechanisms that are active during catabasis. This review provides information on the biosynthesis and actions of these recently identified chemical mediators with particular reference to resolution of mucosal inflammatory responses. (C) 2010 Elsevier Ltd. All rights reserved.
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