Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 82, Issue 1, Pages 45-50Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2009.10.006
Keywords
Cyclooxygenase; Prostaglandin; Bioflavonoids; Co-substrates for cyclooxygenase
Funding
- National Institutes of Health (NIH) [CA97109]
- American Heart Association (AHA) [0910084G]
- NATIONAL CANCER INSTITUTE [R01CA097109] Funding Source: NIH RePORTER
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Bioflavonoids are ubiquitously present in the plant kingdom, and some of them are presently being sold as healthy dietary supplements around the world. Recently, it was shown that some of the dietary polypherrols were strong stimulators of the catalytic activity of cyclooxygenase I and II, resulting in increased formation of certain prostaglandin (PG) products in vitro and also in intact cells in culture. In the present study, we investigated the effect of two representative dietary compounds, quercetin and myricetin, on plasma and tissue levels of several PG products in normal Sprague-Dawley rats. We found that these two dietary bioflavonoids could strongly stimulate the formation of PG products in vivo in a time-dependent manner, and the stimulatory effect of these two bioflavonoids was dose-dependent with a unique biphasic pattern. At lower doses ( < 0.3 mg/kg b.w.), they strongly stimulated the formation of PGE(2), but at higher doses ( > 0.3 mg/kg b.w.), there was a dose-dependent reduction of the stimulatory effect. These results provide support for the hypothesis that some of the bioflavonoids are naturally occurring physiological co-substrates for the cyclooxygenases in vivo. (C) 2009 Elsevier Ltd. All rights reserved.
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