Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 81, Issue 1, Pages 23-29Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2009.05.018
Keywords
n-3 fatty acids; Docosahexaenoic acid; Eicosapentaenoic acid; Erythrocytes; Plasma; Whole blood; Fingertip prick blood; Supplementation; Sex; Blood biomarker
Funding
- University of Waterloo
- Canada Foundation for Innovation
- Ontario Research Fund
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Changes in n-3 highly unsaturated fatty acids (HUFA, >= 20 carbons and >= 3 carbon-carbon double bonds) at baseline, during fish oil supplementation (4 weeks) and during washout (8 weeks) were compared in venous plasma, erythrocytes, whole blood and fingertip prick blood (weeks 0, 4, 8 and 12) with additional weekly fingertip prick samples. Correlations between the various blood fractions were slightly stronger when n-3 HUFA status was expressed as the percentage of n-3 HUFA in total HUFA as compared with the sum of EPA and DHA. Increases and decreases in n-3 HUFA were more dramatic in plasma, and EPA responded rapidly (within I week) with fish oil supplementation and cessation. Sex differences in the proportions of n-3 HUFA in blood were also apparent at baseline with females (n = 7) having a tendency for higher docosahexaenoic acid (DHA, 22:6n-3) relative to eicosapentaenoic acid (EPA, 20:5n-3) and n-3 docosapentaenoic acid (DPAn-3, 22:5n-3) as compared with males (n = 9). Further n-3 biomarker research in larger populations is required. (C) 2009 Elsevier Ltd. All rights reserved.
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