Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 106, Issue -, Pages 16-22Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2013.07.006
Keywords
Lipoxygenase; Neoplastic growth; Tumor biology; Arachidonic acid; Docosahexaenoic acid
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Funding
- Israel Science Foundation [534/09]
- Nutricia Research Foundation
- Marc Rich Foundation
- Teva Pharmaceuticals Ltd.
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Among the lipoxygenases, a diverse family of fatty acid dioxygenases with varying tissue-specific expression, 15-lipoxygenase (15-LOX) was found to be involved in many aspects of human cancer, such as angiogenesis, chronic inflammation, metastasis formation, and direct and indirect tumor suppression. Herein, evidence for the expression and action of 15-LOX and its orthologs in various neoplasms, including solid tumors and hematologic malignancies, is reviewed. The debate surrounding the impact of 15-LOX as either a tumor-promoting or a tumor-suppressing enzyme is highlighted and discussed in the context of its role in other biological systems. (C) 2013 Elsevier Inc. All rights reserved.
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