Journal
ACS Catalysis
Volume 5, Issue 11, Pages 6918-6921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b02090
Keywords
gold catalysis; carboxylic acids; internal alkynes; N-heterocyclic carbenes; cooperativity
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Funding
- ERC
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We report the highly efficient gold-catalyzed hydrocarboxylation of internal alkynes that operates under solvent- and silver-free conditions. This new, simple, and eco-friendly protocol allows for the synthesis of a wide variety of functionalized aryl and alkyl enol esters in high yields, with Z-stereospecificity and good regioselectivities and without the requirement for purification by chromatography. This process represents an expedient, operationally simple method for the synthesis of enol esters.
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