Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 98, Issue 3-4, Pages 94-100Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2011.11.005
Keywords
Cyclo-oxygenase; NSAIDs; Glucocorticoids; Cromones; Lipoxins; Formyl peptide receptors
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Funding
- Arthritis Research UK Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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The action of anti-inflammatory and anti-allergic drugs on the eicosanoid system is briefly reviewed. In addition to the aspirin-like drugs, which directly inhibit the cyclo-oxygenase enzymes, other drugs such as the glucocorticoids and the cromones also inhibit the formation of eicosanoids. In the latter cases this is bought about through the release of a protein factor that acts through formyl peptide receptors on the target cell surface. Of growing interest, is the observation that this receptor is also a target for other eicosanoids, such as lipoxins and resolvins that modulate host defence systems. (C) 2011 Elsevier Inc. All rights reserved.
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