Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 89, Issue 3-4, Pages 120-125Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2008.12.003
Keywords
Arachidonic acid; 12/15-Lipoxygenase; L1236; Eosinophils; 15-HETE
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Funding
- Swedish Cancer Society
- Karolinska Institutet
- Orexo AB
- European Commission [LSHM-CT-2004-005033]
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This mini-review is focused on the enzyme 15-lipoxygenase-1 (15-LO-1) and eoxins in airway inflammatory diseases and Hodgkin lymphoma. Several studies have demonstrated increased expression and activity of 15-LO-1 in the respiratory tissue from asthma patients, indicating a pathophysiological role of this enzyme in airway inflammation. Eoxins were recently identified as pro-inflammatory metabolites of arachidonic acid, formed through the 15-LO-1 pathway, in human eosinophils, mast cells, airway epithelial cells and Hodgkin lymphoma. Mice deficient of 12/15-LO, the ortholog to human 15-LO-1, had an attenuated allergic airway inflammation compared to wild type controls, also indicating a pathophysiological role of this enzyme in respiratory inflammation. The putative therapeutic implications of 15-LO-1 inhibitors in the treatment of asthma, chronic obstructive pulmonary disorder and Hodgkin lymphoma are discussed. (C) 2008 Elsevier Inc. All rights reserved.
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