Journal
PROSTAGLANDINS & OTHER LIPID MEDIATORS
Volume 87, Issue 1-4, Pages 14-19Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2008.05.001
Keywords
Prostaglandin E2; Leukotriene B4; Inflammation; Benign prostate hyperplasia; Prostate cancer
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Funding
- Association de Recherche contre le Cancer
- Centre Hospitalo-Universitaire de Nancy
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PGE2 and LTB4 are involved in inflammation and carcinogenesis in several tissues but have not been studied in prostate cancer and hyperplasia until now. We therefore measured PGE2 and LTB4 productions in a total of 206 prostate tissues from 116 patients including benign hyperplastic (90), pericancerous (106) and cancerous samples (10). We also analysed the influence of inflammation levels, prostate volume and glandular to epithelial ratio. PGE2 and LTB4 concentrations were measured using specific enzyme immunoassay kits. There was a correlation between PGE2 level, prostatic volume, inflammation score, and decreased glandular surface. By contrast, there was no correlation between LTB4 levels and inflammation or PGE2 production. Cancerous samples had higher LTB4 levels than pericancerous samples, but there was no difference in PGE2 levels. PGE2 and inflammation may be associated to stromal benign prostatic hyperplasia whereas LTB4 may play a role in prostate carcinogenesis. (C) 2008 Elsevier Inc. All rights reserved.
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