Journal
ACS Catalysis
Volume 5, Issue 11, Pages 6524-6528Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b01793
Keywords
asymmetric catalysis; nickel; styrene; quaternary stereocenter; sultam
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Funding
- National Natural Science Foundation of P. R. China [21372202]
- New Century Excellent Talents in University [NCET-12-1086]
- Zhejiang Natural Science Fund for Distinguished Young Scholars [LR14B020001]
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Enantioselective addition of styrenes to cyclic N-sulfonyl alpha-ketiminoesters was developed using the complex of Ni(ClO4)(2) with chiral phosphine complex as a catalyst. A range of chiral benzofused 5-membered sultams bearing alkenylated or allylated alpha-tetrasubstituted amino ester framework were afforded in excellent enantioselectivities (up to 99% ee) as potential biologically active compounds for drug research.
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