Journal
ACS CATALYSIS
Volume 5, Issue 12, Pages 7493-7497Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.5b02138
Keywords
C-H activation; cobalt; 1,2-dihydropyridine; 6 pi-electrocylization; well-defined catalyst; mechanistic investigation
Categories
Funding
- CNRS
- MRES
- UPMC
- ANR [ANR-12-BS07-0031- 01COCACOLIGHT]
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A convenient one-pot system has been developed, allowing the synthesis of highly substituted dihydropyridines via a C-H activation/6 pi-electrocyclization pathway. The reaction proceeds with high regioselectivity, and we disclose the first example of isolated dihydropyridines lacking substitution in the 2 position. Moreover, the use of a simple well-defined low-valent cobalt complex without the need for reducing agents or additives in combination with computational studies provides a clearer insight into the C-H activation pathway than was previously reported.
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