Bone-regenerative bioceramic implants with drug and protein controlled delivery capability

Although traditional bioceramics have been widely used in the biomedical field. silica-based ordered mesoporous materials have recently shown interesting properties as drug carriers and well as in bone regeneration. The influence of several host matrix parameters (pore size, surface area, symmetry and surface modification) in drug hosting and controlled delivery is here deeply revised. Also these mesoporous Systems are here investigated as protein delivery systems using Bovine Serum Albumin as protein model. Chemistry offers the possibility of designing novel ordered mesoporous materials, by modifying the composition and the Structure, adapted to the drug structure and their dosage requirements. (C) 2007 Elsevier Ltd. All rights reserved.