Journal
PROGRESS IN RETINAL AND EYE RESEARCH
Volume 39, Issue -, Pages 23-57Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2013.11.001
Keywords
Age-related macular degeneration; AMD; Macular dystrophy; Differential diagnosis; Retina; Clinical characteristics
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Funding
- Niels Stensen Fellowship
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Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population in the Western world. AMD is a clinically heterogeneous disease presenting with drusen, pigmentary changes, geographic atrophy and/or choroidal neovascularization. Due to its heterogeneous presentation, it can be challenging to distinguish AMD from several macular diseases that can mimic the features of AMD. This clinical overlap may potentially lead to misdiagnosis. In this review, we discuss the characteristics of AMD and the macular dystrophies that can mimic AMD. The appropriate use of clinical and genetic analysis can aid the clinician to establish the correct diagnosis, and to provide the patient with the appropriate prognostic information. An overview is presented of overlapping and distinguishing clinical features. (C) 2013 Elsevier Ltd. All rights reserved.
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