Journal
PROGRESS IN RETINAL AND EYE RESEARCH
Volume 37, Issue -, Pages 90-113Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2013.08.003
Keywords
Cuticular drusen; Drusen; Age-related macular degeneration; Complement system; Genetics
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Funding
- Netherlands Organisation for Scientific Research [016.096.309]
- Niels Stensen Fellowship Award
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Cuticular drusen is a specific clinical subtype of age-related macular degeneration (AMD). This subtype of AMD has an earlier age at onset, a stronger familial component, and genetic factors play a more prominent role in its development than in the general AMD population. In this review, we describe the clinical characteristics and differential diagnosis of cuticular drusen, as well as systemic associations including membranoproliferative glomerulonephritis type II. We discuss recent genetic and pathophysiological insights, and future therapeutic perspectives are highlighted. (C) 2013 Elsevier Ltd. All rights reserved.
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