Journal
PROGRESS IN RETINAL AND EYE RESEARCH
Volume 33, Issue -, Pages 40-66Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2012.10.003
Keywords
Gene network; Retina; Photoreceptors; Retinal neurogenesis; Development; Stem cells
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Funding
- Sharon Stewart Research Award
- Canadian Institutes of Health Research [222728]
- Foundation Fighting Blindness - Canada.
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During retinal neurogenesis, diverse cellular subtypes originate from multipotent neural progenitors in a spatiotemporal order leading to a highly specialized laminar structure combined with a distinct mosaic architecture. This is driven by the combinatorial action of transcription factors and signaling molecules which specify cell fate and differentiation. The emerging approach of gene network analysis has allowed a better understanding of the functional relationships between genes expressed in the developing retina. For instance, these gene networks have identified transcriptional hubs that have revealed potential targets and pathways for the development of therapeutic options for retinal diseases. Much of the current knowledge has been informed by targeted gene deletion experiments and gain-of-functional analysis. In this review we will provide an update on retinal development gene networks and address the wider implications for future disease therapeutics. (C) 2012 Elsevier Ltd. All rights reserved.
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