Journal
PROGRESS IN RETINAL AND EYE RESEARCH
Volume 31, Issue 5, Pages 351-376Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2012.04.002
Keywords
Pax6; Lens; Retina; Eye development
Categories
Funding
- Israel Science Foundation [610/10]
- Morasha foundation [1372/11]
- Israel Ministry of Science [36494]
- Ziegler Foundation
- Binational Science Foundation [2007243]
- German Israeli Foundation [1128-156.1/2010]
- Israel Ministry of Health [3-7439]
- Maratie foundation
- Israel-Italy joint innovation program
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Eye development has been a paradigm for the study of organogenesis, from the demonstration of lens induction through epithelial tissue morphogenesis, to neuronal specification and differentiation. The transcription factor Pax6 has been shown to play a key role in each of these processes. Pax6 is required for initiation of developmental pathways, patterning of epithelial tissues, activation of tissue-specific genes and interaction with other regulatory pathways. Herein we examine the data accumulated over the last few decades from extensive analyses of biochemical modules and genetic manipulation of the Pax6 gene. Specifically, we describe the regulation of Pax6's expression pattern, the protein's DNA-binding properties, and its specific roles and mechanisms of action at all stages of lens and retinal development. Pax6 functions at multiple levels to integrate extracellular information and execute cell-intrinsic differentiation programs that culminate in the specification anti differentiation of a distinct ocular lineage. (C) 2012 Elsevier Ltd. All rights reserved.
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