Journal
PROGRESS IN RETINAL AND EYE RESEARCH
Volume 31, Issue 2, Pages 136-151Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2011.11.005
Keywords
CNTF; Photoreceptors; Retinal ganglion cells; Retinal degeneration; Neuroprotection; Photoreceptor plasticity
Categories
Funding
- National Institutes of Health [R01EY12727, R01EY018586, P30EY14801]
- Hope for Vision
- State of Florida
- Department of Defense [W81XWH-09-1-0674]
- Research to Prevent Blindness
- National Institutes of Health, National Eye Institute, and National Institute on Deafness and Other Communication Disorders
Ask authors/readers for more resources
Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia. In addition, CNTF is a neuroprotective factor and an axogenesis factor for retinal ganglion cells (RGCs). This review focuses on the effects of exogenous CNTF on photoreceptors and RGCs in the mammalian retina and the potential clinical application of CNTF for retinal degenerative diseases. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
