Journal
PROGRESS IN POLYMER SCIENCE
Volume 33, Issue 2, Pages 167-179Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2007.09.006
Keywords
photopolymerization; multifunctional monomers; hydrogels; tissue engineering
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [R01 HL089260] Funding Source: Medline
- NIAMS NIH HHS [R01 AR053126-03, R01 AR053126] Funding Source: Medline
- NIDCR NIH HHS [R01 DE016523-03, R01 DE012998, R01 DE012998-08, R01 DE016523] Funding Source: Medline
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Hydrogels formed from the photoinitiated, solution polymerization of macromolecular monomers present distinct advantages as cell delivery materials and are enabling researchers to three-dimensionally encapsulate cells within diverse materials that mimic the extracellular matrix and support cellular viability. Approaches to synthesize gels with biophysically and biochemically controlled microenvironments are becoming increasingly important, and require strategies to control gel properties (e.g., degradation rate and mechanism) on multiple time and size scales. Furthermore, biological responses of gel-encapsulated cells can be promoted by hydrogel degradation products, as well as by the release of tethered biologically relevant molecules. (C) 2007 Elsevier Ltd. All rights reserved.
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