Journal
NATURE COMMUNICATIONS
Volume 6, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/ncomms7178
Keywords
-
Categories
Funding
- Leukaemia Lymphoma Research [LLR 10021, LRF05001, LRF06002]
- Cancer Research UK (Bobby Moore Fund) [C1298/A8362]
- European Union Seventh Framework Programme (FP7) [258236]
- FP7 collaborative project SYSCOL
- Institute of Cancer Research
- Austrian Science Fund (FWF)
- BBSRC [BBS/E/B/000C0404, BBS/E/B/000C0405] Funding Source: UKRI
- Austrian Science Fund (FWF) [J 3269] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0404, BBS/E/B/000C0405] Funding Source: researchfish
- Cancer Research UK [15116] Funding Source: researchfish
Ask authors/readers for more resources
Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined by both restriction fragmentation and sensitivity of the experiment. Here we develop a capture Hi-C (cHi-C) approach to allow an agnostic characterization of these physical interactions on a genome-wide scale. Single-nucleotide polymorphisms associated with complex diseases often reside within regulatory elements and exert effects through long-range regulation of gene expression. Applying this cHi-C approach to 14 colorectal cancer risk loci allows us to identify key long-range chromatin interactions in cis and trans involving these loci.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available