Journal
PROGRESS IN NEUROBIOLOGY
Volume 115, Issue -, Pages 92-115Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2013.11.007
Keywords
Stem cells; Cell-based therapies; Ischemic stroke; Neurorestoration
Categories
Funding
- National Natural Science Foundation of China [31300900, 81300993]
- Jiangsu Provincial Special Program of Medical Science [BL2013025]
- National Institute on Aging of USA [AG031811]
- National Institute of Health of USA [NS057255, NS058710, R41NS080329]
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Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors from host brain cells, thereby enhancing endogenous brain repair processes. Although stem/progenitor cells have shown a promising role in ischemic stroke in experimental studies as well as initial clinical pilot studies, cellular therapy is still at an early stage in humans. Many critical issues need to be addressed including the therapeutic time window, cell type selection, delivery route, and in vivo monitoring of their migration pattern. This review attempts to provide a comprehensive synopsis of preclinical evidence and clinical experience of various donor cell types, their restorative mechanisms, delivery routes, imaging strategies, future prospects and challenges for translating cell therapies as a neurorestorative regimen in clinical applications. (C) 2013 Elsevier Ltd. All rights reserved.
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