Journal
PROGRESS IN NEUROBIOLOGY
Volume 86, Issue 3, Pages 297-303Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2008.08.002
Keywords
Glial cell; GABA; Neuron-glia interaction; Astrocyte
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Funding
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Agence Nationale de la Recherche (ANR)
- Fyssen Foundation
- Federation pour la recherche sur le cerveau (FRC)
- Ministere de l'Education Nationale, de la Recherche et de la Technologie
- Fondation pour la Recherche Medicale (FRM)
- International Brain Research Organization
- Human Frontier Science Program Organization
- Federation Francaise pour la Recherche Sur l'Epilepsie (FFRE)
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The amino acid gamma-aminobutiric acid (GABA) is a major inhibitory transmitter in the vertebrate central nervous system (CNS) where it can be released by neurons and by giial cells. Neuronal GABAergic signaling is well characterized: the mechanisms of GABA release, the receptors it targets and the functional consequences of their activation have been extensively studied. In contrast, the corresponding features of glial GABAergic signaling have attracted less attention. In this review, we first discuss evidence from the literature for GABA accumulation, production and release by glial cells. We then review the results of recent experiments that point toward functional roles of GABA as a gliotransmitter. (C) 2008 Elsevier Ltd. All rights reserved.
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