Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 35, Issue 6, Pages 1421-1431Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2010.11.035
Keywords
Anxiety; Anxiolytic drugs; Anxiogenic drugs; Novelty-based paradigms; Novel tank test; Zebrafish
Funding
- Tulane University
- Provost's Scholarly Enrichment Fund
- Lurcy Fellowships
- Zebrafish Neuroscience Research Consortium (ZNRC)
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Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research. (C) 2010 Elsevier Inc. All rights reserved.
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