Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 33, Issue 7, Pages 1245-1249Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2009.07.012
Keywords
Bipolar disorder; Hypothalamic-pituitary-adrenal axis; Magnetic resonance imaging; Pituitary gland
Funding
- Neurosciences Victoria
- Japanese Society for the Promotion of Science [19591346]
- Ministry of Health and Welfare, Japan [17-2, 18-6]
- NHMRC Clinical Career Developmental Award [509345, 510135]
- NARSAD Young Investigator Award
- Pfizer Neuroscience Research
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Hypothalamic-pituitary-adrenal (HPA) axis dysfunction has been demonstrated in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have reported variable findings. In this MRI study we investigated pituitary volume in 26 patients with established bipolar I disorder (8 males and 18 females, mean age = 38.4 years) and 24 matched controls (7 males and 17 females, mean age = 38.7 years). The BD patients had a significantly larger pituitary volume as compared with controls, but there was no association between pituitary volume and illness duration, number of manic/depressive episodes, daily medication dosage, family history, or clinical subtype (i.e., psychotic and nonpsychotic). Pituitary volume was larger in females than in males for both groups. These results support previous neuroendocrine findings that implicate HPA axis dysfunction in the core pathophysiological process of BD. (C) 2009 Elsevier Inc. All rights reserved.
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