Journal
PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
Volume 23, Issue 5, Pages 481-486Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.pnsc.2013.09.002
Keywords
Mach-Zehnder interferometer; Young interferometer; Lab on a chip; Arrayed biosensors; Evanescent field detection
Funding
- University of Nottingham Ningbo China
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This paper reported the optimal design of label-free silicon on insulator (SOI lab on a chip biosensors. These devices are designed on the basis of the evanescent field detection principles and interferometer technologies. The well-established silicon device process technology can be applied to fabricate and test these biosensor devices. In addition, these devices can be monolithically integrated with CMOS electronics and microfluidics. For these biosensor devices, multi-mode interferometer (MMI) was employed to combine many stand-alone biosensors to form chip-level biosensor arrays, is enable real-time and label free monitoring and parallel detection of various analytes in multiple test samples. This sensing and detection technology features the highest detection sensitivity, which can detect analytes at extremely low concentrations instantaneously. This research can lead to innovative commercial development of the new generation of high sensitivity bioseasors for a wide range of applications in many fields, such as environmental monitoring, food security control, medical and biological applications. (C) 2013 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved.
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