Journal
PROGRESS IN LIPID RESEARCH
Volume 72, Issue -, Pages 42-54Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2018.09.001
Keywords
Stem cells; Lysophosphatidic acid; Sphingosine-1-phosphate
Funding
- Australian Research Council [FT140100047]
- National Health and Medical Research Council [1042589, 430907]
- CERA Foundation
- Fay Fuller Foundation
- Neurosurgical Research Foundation
- University of Melbourne
- Stem Cells Australia - the Australian Research Council Special Research Initiative in Stem Cell Science
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Stem cells are unique in their ability to self-renew and differentiate into various cell types. Because of these features, stem cells are key to the formation of organisms and play fundamental roles in tissue regeneration and repair. Mechanisms controlling their fate are thus fundamental to the development and homeostasis of tissues and organs. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are bioactive phospholipids that play a wide range of roles in multiple cell types, during developmental and pathophysiological events. Considerable evidence now demonstrates the potent roles of LPA and SW in the biology of pluripotent and adult stem cells, from maintenance to repair. Here we review their roles for each main category of stem cells and explore how those effects impact development and physiopathology.
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