Journal
PROGRESS IN LIPID RESEARCH
Volume 54, Issue -, Pages 14-31Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2014.01.002
Keywords
Lipid biosynthesis; Lipid metabolism; Metabolic profiling; Stable isotope labeling; Mass spectrometry; Lipidomics
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Nature provides an enormous diversity of lipid molecules that originate from various pathways. To gain insight into the metabolism and dynamics of lipid species, the application of stable isotope-labeled tracers combined with mass spectrometric analysis represents a perfect tool. This review provides an overview of strategies to track fatty acid, glycerophospholipid, and sphingolipid metabolism. In particular, the selection of stable isotope-labeled precursors and their mass spectrometric analysis is discussed. Furthermore, examples of metabolic studies that were performed in cell culture, animal and clinical experiments are presented. (C) 2014 Elsevier Ltd. All rights reserved.
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