Journal
PROGRESS IN LIPID RESEARCH
Volume 52, Issue 4, Pages 562-570Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2013.08.004
Keywords
Astrocytoma; Arachidonic acid; Docosahexaenoic acid; Fatty acid binding protein; Eicosanoids; Lipid metabolism; Malignant glioma
Funding
- Alberta Cancer Foundation
- Canadian Institutes of Health Research
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Malignant gliomas are the most common adult brain cancers. In spite of aggressive treatment, recurrence occurs in the great majority of patients and is invariably fatal. Polyunsaturated fatty acids are abundant in brain, particularly omega-6 arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA). Although the levels of omega-6 and omega-3 polyunsaturated fatty acids are tightly regulated in brain, the omega-6:omega-3 ratio is dramatically increased in malignant glioma, suggesting deregulation of fundamental lipid homeostasis in brain tumor tissue. The migratory properties of malignant glioma cells can be modified by altering the ratio of AA:DHA in growth medium, with increased migration observed in AA-rich medium. This fatty acid-dependent effect on cell migration is dependent on expression of the brain fatty acid binding protein (FABP7) previously shown to bind DHA and AA. Increased levels of enzymes involved in eicosanoid production in FABP7-positive malignant glioma cells suggest that FABP7 is an important modulator of AA metabolism. We provide evidence that increased production of eicosanoids in FABP7-positive malignant glioma growing in an AA-rich environment contributes to tumor infiltration in the brain. We discuss pathways and molecules that may underlie FABP7/AA-mediated promotion of cell migration and FABP7/DHA-mediated inhibition of cell migration in malignant glioma. (C) 2013 Elsevier Ltd. All rights reserved.
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